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Active Pharmaceutical Intermediates

S.No Product Name Intermediate CAS No Therapeutic Use
1
 Alcaftadine N-Methyl-4-chloro piperidine 5570-77-4 Antihistamine
2
 Amitriptyline HCl & Nortriptyline HCl Dibenzosuberone 1210-35-1 Antidepressant
3-(N,N, di methyl amino) propylchloride HCl 5407-04-5
3
 Bepotastine Besilate N-carbethoxy-4-hydroxypiperidine 65214-82-6 Antihistaminic
α-(-4-Chlorophenyl) pyridine -2-methanol 27652-89-7
2-((4-Chlorophenyl) (4-piperdinyloxy) methyl pyridine 122368-54-1
4-Hydroxypiperidine 5382-16-1
4-[(4-Chlorophenyl)-2-pyridylmethoxy]piperidine p-nitrobenzoic acid salt 161558-45-8
4
 Brigatinib 1-methyl-4-(piperidin-4-yl)-piperazine 53617-36-0 Metastatic non-small cell lung cancer
5
 Cinnarizine and Flunarizine 1-(Diphenyl methyl) piperazine 841-77-0 Antihistaminic
6
 Cyclobenzaprine HCl Dibenzosuberenone 2222-33-5 Muscle Relaxant
3-(N,N Di methyl amino) propylchloride HCL 5407-04-5
7
 Cyproheptadine HCl Dibenzosuberenone 2222-33-5 Anti Allergic
N-Methyl-4-chloro piperidine 5570-77-4
8
 Dabigatran Etexilate Mesylate 3-[[[2-[[4-(Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester 211915-84-3 Antithrombotic
N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 429658-95-7
Ethyl 3-(((2-(((4-(((hexyloxy) carbonyl) amino)iminomethyl) phenyl) amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)(pyridin-2-yl)amino) propanoate 211915-06-9
9
 Domperidone 1-(3-Chloropropyl)-1,3-dihydro-1H-benzimidazol-2-one 62780-89-6 Antiemetic
5-Chloro 1,3 dihydro -1- (4-piperidinyl) -2H-benzimidazol - 2 -one 53786-28-0
10
 Donepezil 4-[(5,6-Dimethoxy-1-indanon-2-yl) methyl] piperidine 120014-30-4 Nootropic
5,6-dimethoxy-2-(pyridine-4-yl)-methylene-indan-1-one 4803-74-1
(2RS)-2-[(1-Benzylpiperidin-4-yl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one (Base) 120014-06-4
11
 Ebastine 4-Tert butyl-4-chlorobutyrophenone 43076-61-5 Antihistaminic
12
 Eprosartan 2-Butyl-1H-imidazole-5-carboxaldehyde 68282-49-5 Antihypertensive
13
 Febuxostat Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 Antihyperuricemic
Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161798-01-2
Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161798-02-3
Ethyl-2-(3-Formyl-4-isobutoxy phenyl)-4-methyl-1,3-thiazole-5-carboxylate 161798-03-4
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 160844-75-7
14
 Flunarizine Di-HCl 1-[bis(4-fluorophenyl)methyl]piperazine (OR) 4,4'-Difluorobenzhydrylpiperazine 27469-60-9 Antihistaminic
15
 Gadobutrol (Cyclen intermediate) 1,4,7,10-Tetraazacyclododecane 294-90-6 MRI contrast agents
16
 Golvatinib & Gilteritinib 1-N-Methyl-4-(4-piperidin-4-yl)-piperazine 53617-36-0 Anticancer
17
 Haloperidol 4-Chloro-4'-fluoro-butyrophenone 3874-54-2 Antipsychotic
4-(4-Chlorophenyl)-4-hydroxy piperidine 39512-49-7
18
 Indoramin HCl 4-Benzamido piperidine 33953-37-6 Antiadrenergic
19
 Ketotifen N-Methyl-4-chloro-piperidine 5570-77-4 Antiasthamatic & Anti Allergic
20
 Linagliptin (R)-3-(boc-amino) piperidine 309956-78-3 Antidiabetic
(R)-3-Piperidinamine dihydrochloride 334618-23-4
21
 Loperamide HCl 4-(4-Chlorophenyl)-4-hydroxy piperidine 39512-49-7 Antidiarrheal
N,N-Dimethyl(tera hydro-3,3-diphenyl)-2-furylidene ammonium bromide (furanuminium bromide) 37743-18-3
α, α-Diphenyl-γ-butyrolactone 956-89-8
4-Bromo-2-2-diphenylbutyric acid 37742-98-6
22
 Loratadine & Desloratadine 3-[2-(3Chlorophenyl) ethyl)-2-cyano pyridine 31255-57-9 Antihistaminic
8-Chloro-5,6 dihydro(11H)-benzo[5,6] cyclohepta (1,2b) pyridine -11-one 31251-41-9
8 Chloro-11-[(N-methyl)-4-piperidylidene]-6,11-dihydro-5H-benzo [5,6]cyclohepta (1,2b) pyridine (methyl loratadine) 38092-89-6
{3-[2-(3-Chlorophenyl)ethyl]pyridine-2-yl}-(1-methyl piperidine-4-yl) (methanone HCl) 119770-60-4
N-Methyl-4-chloro piperidine 5570-77-4
23
 Losartan Potassium 2-N-Butyl-4chloro-1-[2''-H tetrazol-5-yl)(1,1'-biphenyl)-4yl)methyl]-1H imidazole-5-methanol (losartan base) 11479-26-4 Anti-hypertensive
2-N-Butyl-4-chloro-5-Formylimidazole (BCFI) 83857-96-9
24
 Mirabegron (R)-N-(4-nitrophenethyl)-2-hydroxy-2-phenylacetamide 521284-19-5 Over active bladder
(R)-2-(4-nitrophenethylamino)-1-phenylethanol.HCl 521284-21-9
(R)-2-(4-aminophenethylamino)-1-phenylethanol 521284-22-0
25
 Oxatomide 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one 62780-89-6 Antiallergic / Antiasthamatic
1-(Diphenyl methyl) piperazine 841-77-0
26
 Pemetrexed 4-[2-(2-Amino-4,7-Dihydro-4-Oxo-1H-Pyrrolo[2,3-D]Pyrimidin-5-YL)Ethyl] Benzoic Acid 137281-39-1 Anti cancer
27
 Pimozide 4-(2-Keto-1-benzimidazolinyl) piperidine 20662-53-7 Antipsychotic
1-Chloro-4,4-di (4-fluorophenyl)butane 3312-04-7
28
 Prucalopride 1-(3-Methoxy propyl) piperidine-4-one 16771-85-0 Gastroprokinetic
1-(3-Methoxypropyl)-4-Piperidinamine 179474-79-4
29
 Rifabutin 1-Isobutyl-4-piperidone 72544-16-2 Antibacterial
30
 Rimegepant Sulfate Hydrate 1,3-Dihydro-1-[1-(1H-imidazol-1-ylcarbonyl)-4-piperidinyl]-2H-imidazo[4,5-b] pyridin-2-one (Intermediate-1) 1373116-06-3 Prevent migraine headaches by blocking CGRP receptors
(5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridin-5-amine dihydrochloride (Intermediate-2) 1373116-04-1
31
 Rivaroxaban 4-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone (or) 1H-isoindole-1,3 (2H)-Dione, 2-[[(5S)-2-Oxo-3-[4-(3-Oxo-4Morpholinyl)Phenyl]-5-Oxazolidinyl]methyl] 446292-08-6 Antithromobotic
4-(4-((S)-5-(Aminomethyl)-2-oxooxazolidin-3-Yl) phenyl)morpholin-3-one HCl 898543-06-1
32
 Ropivacaine Hydrochloride Monohydrate (S)-N,-(2-6-dimetylphenyl)piperidine-2-carboxamide 27262-40-4 Local anesthetic
33
 Rupatadine Fumarate 3-Chloromethyl-5-methyl pyridine HCl 1007089-84-0 Antihistaminic
34
 Selexipag 4-(Isopropylamino)butanol 42042-71-7 Pulmonary arterial hypertension
35
 Tamsulosin R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide 112101-81-2 In treatment of benign prostatic hyperplasia
5-[2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide (R-Isomer of Tamsulosin base) 106133-20-4
36
 Trazadone [1,2,4]triazolo[4,3-a]pyridin-3-one 6969-71-7 Antidepressant
1-(3-chlorophenyl)-4-(3-chloropropyl) 52605-52-4
37
 Tucatinib N-(4-Amino-2-Cyanophenyl)-N,N-Dimethanimidamide 194423-17-1 Astric ulcer, duodenal ulcer and reflux esophagitis
38
 Vonoprazan Fumarate 5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carboxaldehyde 881677-11-8 Astric ulcer, duodenal ulcer and reflux esophagitis
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